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isoniazid will raise the degree or result of pazopanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Avoid coadministration of pazopanib with potent CYP3A4 inhibitors if possible; if need to coadminister, lessen pazopanib dose to 400 mg/daypazopanib will improve the amount or result of tadalafil by affecting hepatic/i